The most common side effects of Ozempic are problems with the digestive system, such as nausea, vomiting and diarrhoea. They may affect more than 1 in 10 people and are usually mild or moderate and short-lived, according to the European Medicines Agency.
- Who it is licensed for
- Adults with type 2 diabetes that is not well controlled, with diet and exercise. The weight licences (Wegovy, Mounjaro) cover a BMI of 30 or more, or 27 or more with a weight-related condition. The UK medicines regulator says these medicines should not be used to lose weight for cosmetic reasons.
- If you have diabetes
- The European Medicines Agency also lists serious worsening of diabetic retinopathy, an eye condition, as a common side effect that may affect up to 1 in 10 people. Tell Dr. Rockhead about any eye problems.
- If you take other diabetes medicines
- Low blood sugar is very common when Ozempic is used together with insulin or a sulphonylurea, according to its product information. Tell Dr. Rockhead about every medicine you take.
- Who should not take a GLP-1 medicine
- An allergy to the medicine; you or anyone in your family has had medullary thyroid cancer or MEN 2 (a condition that causes tumours in more than one gland); severe stomach or bowel disease; a history of pancreatitis; pregnancy or breastfeeding.
- The thyroid warning
- US labels carry a boxed warning because these medicines caused thyroid tumours in rats. Whether they do in people is unknown.
- Pregnancy and breastfeeding
- Ozempic should not be used during pregnancy or while breastfeeding, and should be stopped at least 2 months before a planned pregnancy, according to its product information. Use reliable contraception while you are taking it. Tell Dr. Rockhead which contraception you use, and tell him if you are planning a pregnancy.
- Never combine; beware of fakes
- Do not take it with another GLP-1 or weight-loss medicine. The FDA warned in 2025 that fake Ozempic pens reached the US supply chain, and the UK regulator says never to buy from salons or social media.
- Before surgery or sedation
- Tell your surgeon and your anaesthetist that you take this medicine. Its product information warns that food can stay in the stomach longer, which matters under general anaesthesia or deep sedation.
- Go to a hospital at once
- For severe stomach pain that does not go away, sometimes spreading to your back, which can be pancreatitis; swelling of the face, lips, tongue or throat, or trouble breathing; or a sudden change in your sight.
- Call us
- On (876) 676-6297 for pain in the upper stomach with yellow skin or eyes, fever or pale stools; passing much less urine, or swollen legs; a lump in your neck, hoarseness or trouble swallowing; unusual nausea, vomiting or stomach pain; or any new symptom. Drink plenty after vomiting or diarrhoea; severe dehydration may need a hospital. If you cannot reach us, see a doctor.
- The full list
- The package leaflet lists all side effects and restrictions. Ask for it, read it, and ask at your monthly visit about anything in it.